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Benefits of an Exclusive Human Milk Diet (EHMD)

More than 20 clinical studies with more than 5,000 premature infants have demonstrated the effectiveness of Prolacta’s 100% human milk–based nutritional products.1

Our products, as part of an EHMD, have been shown in clinical studies to:

  • Significantly reduce the risk of complications and feeding intolerance associated with cow milk–based fortifiers2,3,4,5
  • Fortify early to safely nourish the preterm infant to ensure healthy gut, lung, and brain development, as well as achieve healthy growth6,7,8

Our products

Prolacta’s human milk–based nutritional products contain a wide range of human milk oligosaccharides (HMOs)—special sugars abundantly found in human milk.9 HMOs promote the development and maturation of the newborn immune system and provide a supplementary source of sialic acid critical for brain development. 10,11

Prolact+ H2MF

Prolact+ H2MF is the first commercially available human milk fortifier made from 100% human milk.

  • Intended for premature/low-birth-weight infants (weighing under 1500g at birth)
  • Helps to ensure healthy gut, lung, and brain development, as well as achieve healthy growth6,7,8
  • Retains human milk oligosaccharide content similar to that of fresh human milk9

Prolact CR® Human Milk Caloric Fortifier

Human milk caloric fortifier is ideal for neonatal infants receiving low caloric content. Data show that 65% of the time, term mother’s own milk (MOM) is less than 20 Cal/fl oz.12 Prolact CR human milk caloric fortifier can meet the need for additional calories.

  • Intended for use with MOM or donor milk (DM) to increase lipids and achieve adequate growth
  • Formulated to deliver at least 2.6 Cal/mL
  • Available frozen in 30 mL bottles containing 10 mL of product
    (4 bottles per unit carton, with 48-hour expiration)
  • Includes simplified preparation instructions
  • Easy to use and measure

Prolact CR human milk caloric fortifier is the only completely human solution created to add calories to MOM or DM without substantially increasing volume and without introducing a non-human milk-based nutritional product.

A randomized clinical trial found that premature infants who received an exclusive human milk diet (EHMD) with Prolact CR fortifier had superior length and weight velocity compared to infants who received an EHMD without Prolact CR fortifier.13

Preterm infants who received Prolact CR fortifier had a significantly earlier post-menstrual age (PMA) at discharge and trended toward decreased length of stay when compared to those who did not receive Prolact CR fortifier.14,15

This study is a subset analysis of data originally published in 2014 by Hair et al in The Journal of Pediatrics.

Clinical Studies and Publications:

  • Randomized Trial of Human Milk Cream as a Supplement to Standard Fortification of an Exclusive Human Milk-Based Diet in Infants 750-1250 g Birth Weight
  • Premature Infants 750–1,250g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner
  • Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk
  • Macronutrient analysis of a nationwide sample of donor breast milk

Product information downloads

Supplemental product info

Product specification sheet

Preparation guidelines

Nutrition information

Prolact CR preparation log sheet

Prolact RTF

Prolact RTF (Ready-To-Feed) offers Neonatal Intensive Care Units superior solutions for their extremely premature infants when mother’s own milk is not available.

Human Milk-Based Premature Infant Formula

  • Provides an easy, convenient, labor saving way to provide 100% human milk-based diet when mother’s own milk is unavailable
  • A more cost-effective way to provide an exclusive human milk diet comprised of Prolact HM® and Prolact+ H2MF®
  • Reduces the chance of mixing errors and saves time
  • Shorter duration of TPN for infants fed an Exclusive Human Milk-based Diet vs. cow milk-based preterm formula4
  • Significantly fewer surgical NEC cases for infants fed an Exclusive Human Milk-based Diet vs. cow milk-based preterm formula4

Human donor milk

Pasteurized, standardized, quality human donor milk

The benefits of breastmilk are well established, and breastfeeding is highly recommended by healthcare professionals.

Since 2012, the American Academy of Pediatrics (AAP) has recommended the use of human milk for all preterm infants, whether MOM or pasteurized human donor milk, if MOM is unavailable.11

Guaranteed supply

Only Prolacta offers a guaranteed supply of donor human milk based on your NICU’s usage forecast – that means no more worrying about supply shortages.12

Standardized nutrition

  • The first donor human milk formulated to a minimum of 20 kcal/fl oz
  • The first donor human milk to provide an average of 1.0 g protein/100 mL1
  • Two-year shelf life supported by real-time stability studies on every batch1
  • Available in two sizes for flexibility in feeding premature infants
  • Can be administered within 48 hours once the thawing process begins1
  • Labeled in accordance with U.S. FDA food labeling requirements

Industry-leading quality and safety

  • The only donor human milk verified by DNA matching to the donor
  • Milk is tested for B. cereus and for adulteration, nicotine, and drugs of abuse
  • Each donation is tested using nucleic acid testing for HIV-1 & 2, HTLV I & II, HBV, HCV, syphilis, and ZIKV
  • Processed in a pharmaceutical-grade manufacturing facility

Product information downloads

Prolact HM® Product Specification Sheet

Prolact HM® Supplemental Product Info

Prolact HM® Preparation Log Sheet

PremieLact Product Specification Sheet

PremieLact Supplemental Product Info

PremieLact Preparation Log Sheet

Overcoming complications

Prolacta’s products, when used as part of an EHMD, have been shown to reduce the incidence of clinical complications.

In a multicenter, retrospective cohort study with 1587 patients, the outcomes of extremely premature infants (<1250 g birth weight) who received a diet including cow milk–based products were compared with infants who received an EHMD. The incidence of mortality, necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), and late-onset sepsis were all reduced with an EHMD.13





Improving outcomes with Prolacta's EHMD

  • Decreasing feeding intolerance – Prolacta's EHMD was associated with a lower incidence of feeding intolerance and shorter time to full feeds compared to a diet containing cow milk-based products2
  • Supporting adequate growth – An EHMD feeding protocol for infants with a birthweight of ≤1250 g that enables early and rapid fortification advancement is associated with weight, length, and head circumference gains meeting targeted standards, and with a low rate of extrauterine growth restriction6,7,13
  • Turning to nutrition to address the complications of prematurity – Today, more and more hospitals are turning to Prolacta’s fortifiers that are clinically proven as part of an EHMD; this nutritional solution is shown in a growing body of evidence to reduce the most serious complications of prematurity2,7,14,16

Reducing hospital costs with an EHMD

Very low birth weight babies are at risk for prematurity-related morbidities and interventions, such as BPD, ROP, late-onset sepsis, and NEC. The incremental cost of these morbidities and interventions can substantially increase the cost of NICU hospitalization.

“Despite the added cost of donor human milk and donor milk–derived fortifier, an EHMD is cost-effective.”2

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